GENECOUNTING: haplotype analysis with missing genotypes
نویسندگان
چکیده
منابع مشابه
GENECOUNTING: haplotype analysis with missing genotypes
A general algorithm is described for haplotype analysis of unrelated individuals with missing genotypes. It can handle problems involving multiple polymorphic markers with missing data.
متن کاملModeling Informatively Missing Genotypes in Haplotype Analysis.
It is common to have missing genotypes in practical genetic studies. The majority of the existing statistical methods, including those on haplotype analysis, assume that genotypes are missing at random-that is, at a given marker, different genotypes and different alleles are missing with the same probability. In our previous work, we have demonstrated that the violation of this assumption may l...
متن کاملHaplotype Inference on Pedigrees with Recombinations, Errors, and Missing Genotypes via SAT solvers
The Minimum-Recombinant Haplotype Configuration problem (MRHC) has been highly successful in providing a sound combinatorial formulation for the important problem of genotype phasing on pedigrees. Despite several algorithmic advances and refinements that led to some efficient algorithms, its applicability to real datasets has been limited by the absence of some important characteristics of thes...
متن کاملHaplotype analysis in the presence of informatively missing genotype data.
It is common to have missing genotypes in practical genetic studies, but the exact underlying missing data mechanism is generally unknown to the investigators. Although some statistical methods can handle missing data, they usually assume that genotypes are missing at random, that is, at a given marker, different genotypes and different alleles are missing with the same probability. These inclu...
متن کاملImputing missing genotypes with weighted k nearest neighbors.
Missing values are a common problem in genetic association studies concerned with single-nucleotide polymorphisms (SNPs). Since many statistical methods cannot handle missing values, such values need to be removed prior to the actual analysis. Considering only complete observations, however, often leads to an immense loss of information. Therefore, procedures are required that can be used to im...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bioinformatics
سال: 2002
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/18.12.1694